Sale!

Fundamentals of Biochemistry 4th Edition Voet Pratt Test Bank

$80.00 $11.99

Fundamentals of Biochemistry 4th Edition Voet Pratt Test Bank

ISBN-13: 978-1118129180

ISBN-10: 1118129180

 

 

Description

Fundamentals of Biochemistry 4th Edition Voet Pratt Test Bank

ISBN-13: 978-1118129180

ISBN-10: 1118129180

 

 

 

How can a nursing test bank help me in school?

  Think about it like this. You have one text book in your class. So does your teacher. Each text book has one test bank that teachers use to test students with. This is the nursing test bank for the book you have. All authentic chapters and questions and answers are included.

Do I get to download this nursing test bank today?

Since we know that students want their files fast, we listened and made it exactly the way you want. So you can download your entire test bank today without waiting for it.

Is this site anonymous and discreet?

We try our best to give nursing students exactly what they want. So your order is 100 percent anonymous and discreet. We do not keep any logs of any kind on our website and use a 256 bit SSL encryption on our site which you can verify.

What if I order the wrong test bank?

As long as the file is not downloaded, we can give you the correct file. Please send us an email and we will send you the correct file right away.

Can I request a sample before I purchase to make sure its authentic?

Of coarse you can, samples are provided on this page as well. Please scroll down to view a sample. If it is not on this page, email us and we will send you a free sample chapter which you can view before your purchase.

What format are the nursing test banks in when I download them?

Most of the formats are going to be in a PDF format. We also have files in Microsoft Word. They can be viewed on your computer or phone.

Can I write a review and leave a testimonial on this site?

You certainly can. Please email us by sending an email to us. Many students send us emails thanking us for helping them.

Below you will find some free nursing test bank questions from this test bank:

Chapter 23: Nucleotide Metabolism

 

Matching

Choose the correct answer from the list. Not all the answers will be used.

A) fumarate
B) NADPH
C) salvage
D) uric acid
E) oxidation
F) XMP
G) iron
H) allopurinol
I) IMP
J) oxidation
K) therapeutic
L) suicide
M) molybdenum
N) FADH
O) Malonyl-CoA
P) reduction
Q) antifolate

 

  1. The precursor to AMP and GMP is ______.

Ans:  I

Section: 23.1.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

  1. In purine synthesis the byproduct released when aspartate functions as an amino group donor is ________.

Ans:  A

Section: 23.1.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

  1. During the turnover of nucleic acids some purines can be reincorporated into nucleotides via _____ pathways.

Ans:  C

Section: 23.1.D

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Deoxyribonucleotides are synthesized by ______ of the corresponding  ribonucleotide’s  2¢

Ans:  P

Section: 23.3.A

Level of Difficulty: Easy

Learning Objective: Formation of Deoxyribonucleotides

 

  1. Class I ribonucleotide reductases (RNR) contain a(n) ______ prosthetic group.

Ans:  G

Section: 23.3.A

Level of Difficulty: Easy

Learning Objective: Formation of Deoxyribonucleotides

  1. The electrons used to convert an NDP to a dNDP ultimately come from ______.

Ans:  B

Section: 23.3.A

Level of Difficulty: Easy

Learning Objective: Formation of Deoxyribonucleotides

  1. Mechanism-based inhibitors are also called _____ substrates.

Ans:  L

Section: 23.3.B

Level of Difficulty: Easy

Learning Objective: Formation of Deoxyribonucleotides

  1. ______ compounds are effective anticancer agents.

Ans:  Q

Section: 23.3.B

Level of Difficulty: Easy

Learning Objective: Formation of Deoxyribonucleotides

  1. Purines are degraded to ______.

Ans:  D

Section: 23.4.A

Level of Difficulty: Easy

Learning Objective: Nucleotide Degradation

  1. Gout is treated using the compound ______.

Ans:  H

Section: 23.4.B

Level of Difficulty: Easy

Learning Objective: Nucleotide Degradation

 

 

Multiple Choice

  1. John Buchanan began the elucidation of the synthesis of purine nucleotides by studying _______ excreted by pigeons fed isotopically labeled compounds.
    1. xanthine
    2. hypoxanthine
    3. uric acid
    4. b-alanine
    5. b-aminoisobutyrate

 

Ans: C

Section: 23.1

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Hydroxylation of IMP to form GMP occurs in conjunction with the ________ of _______.
    1. oxidation; NADH
    2. reduction; NAD+
    3. oxidation; NADPH
    4. reduction; NADP+
    5. none of the above

Ans: B

Section: 23.1.B

Level of Difficulty: Moderate

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. The symptoms of Lesch–Nyhan syndrome are caused by a deficiency of which of the following enzymes?
    1. adenine phosphoribosyltransferase
    2. HGPRT (hypoxanthine–guanine phosphoribosyltransferase)
    3. adenosine deaminase
    4. dihydrofolate reductase
    5. xanthine oxidase

Ans:  B

Section: 23.1.D

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

 

 

 

 

 

 

 

  1. The first step in pyrimidine biosynthesis is the formation of
    1. carbamoyl phosphate.
    2. carbamoyl aspartate.
    3. β-aminoisobutyrate.
    4. none of the above

Ans:  A

Section: 23.2.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Pyrimidine Ribonucleotides

 

  1. Which of the following correctly describes the formation of CTP?
    1. UTP + Glutamine + ATP + H2O ® Glutamate + ADP + Pi + CTP
    2. UMP + ATP + H2O + Glutamine ® CMP + Glutamate + ADP + Pi
    3. TTP + N5,N10-Methylenetetrahydrofolate ® CTP + Dihydrofolate
    4. UMP + Glutamine ® Glutamate + CTP
    5. CMP + Glutamine + ATP ® CTP + Glutamate + ADP + Pi

 

Ans:  A

Section: 23.2.B

Level of Difficulty: Easy

Learning Objective: Synthesis of Pyrimidine Ribonucleotides

 

  1. The synthesis of the dNTPs required for DNA production must be controlled by ________ in order to ensure minimal ________ activity from excess of one dNTP over the other dNTPs.
    1. feedback inhibition; mutagenic
    2. feed forward activation; synthesis
    3. substrate availability; mutagenesis
    4. secondary messenger systems; synthesis
    5. feed forward; mutagenic

 

Ans:  A

Section:  23.3.A

Level of Difficulty: Moderate

Learning Objective: Formation of Deoxyribonucleotides

 

 

 

 

 

 

 

 

 

 

  1. Which of the choices correctly represents the synthesis of dTTP as represented by the following reactions?
  2. dUMP + N5,N10-methylenetetrahydrofolate ® dTMP + dihydrofolate
  3. dTMP + ATP ® dTTP + Pi

III. dUTP + H2O ® dUMP + PPi

  1. dUTP + N5,N10-methylenetetrahydrofolate ® dTTP + dihydrofolate
    1. I ® II ® IV
    2. IV only
    3. III ® IV ® I ® II
    4. III ® I ® II
    5. III ® I

Ans:  D

Section: 23.3.A,B

Level of Difficulty: Difficult

Learning Objective: Formation of Deoxyribonucleotides

 

 

  1. The conversion of dUMP to dTMP by thymidylate synthase requires which of the following cofactors?
  2. thioredoxin
  3. N5,N10-methylenetetrahydrofolate

III.    S-adenosylmethionine

  1. I and II
  2. I only
  3. II only
  4. II and III
  5. I and III

Ans: C

Section: 23.3.B

Level of Difficulty: Moderate

Learning Objective: Formation of Deoxyribonucleotides

 

  1. Myoadenylate deaminase deficiency is most evident in ______ tissue.
    1. liver
    2. connective
    3. neural
    4. muscle
    5. brain

Ans: D

Section: 23.4.A

Level of Difficulty: Easy

Learning Objective: Nucleotide Degradation

 

  1. Which of the following organisms excrete uric acid?
  2. primates
  3. marine invertebrates

III.    insects

  1. mammals other than primates
    1. I, IV
    2. I, III
    3. IV only
    4. I only
    5. II, III

Ans: B

Section: 23.4.B

Level of Difficulty: Easy

Learning Objective: Nucleotide Degradation

 

  1. Which of the following is not required for purine biosynthesis?
  2. aspartate
  3. glycine

III. glutamine

  1. formyl addition to tetrahydrofolate
    1. I only
    2. II, IV
    3. II, III
    4. IV only
    5. All of the above are required.

Ans: E

Section:  23.1.A

Level of Difficulty: Moderate

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Atoms from which of the following amino acids are utilized in pyrimidine biosynthesis?
  2. glutamine
  3. glycine

III.     asparagine

  1. aspartate
    1. I, II
    2. III
    3. I, IV
    4. II, III
    5. II, IV

Ans: C

Section: 23.2.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Pyrimidine Ribonucleotides

 

 

  1. The proposed mechanism of the Class I RNR involves
    1. electron transfer directly from substrate to tyrosine 122.
    2. electron transfer from substrate to various cysteine residues.
    3. an exposed tyrosine which accepts an electron from the ribosyl radical.
    4. electron donation to external reducing agents.
    5. none of the above

Ans:  B

Section: 23.3.A

Level of Difficulty: Difficult

Learning Objective: Formation of Deoxyribonucleotides

 

  1. The thymidylate synthase reaction is unique because
    1. THF is regenerated by the same enzyme.
    2. THF is regenerated via a two-step reaction.
    3. THF is oxidized to DHF; no other reaction alters the THF oxidation state.
    4. None of the above is correct.
    5. All of the above are correct.

Ans:  C

Section: 23.3.B

Level of Difficulty: Difficult

Learning Objective: Formation of Deoxyribonucleotides

 

  1. Which of the following statements about nucleotide synthesis is (are) true?
  2. Most dietary nucleotides are salvaged and used in DNA synthesis.
  3. Most nucleotides in cells are from de novo pathways.

III.     Most nucleotides in cells are salvaged and used in RNA synthesis.

  1. I, II
  2. I only
  3. II only
  4. II, IV
  5. III only

Ans: C

Section: 23.4

Level of Difficulty: Moderate

Learning Objective: Nucleotide Degradation

 

  1. Which of the following sequences for uric acid catabolism is correct for marine invertebrates?
    1. uric acid ®allantoin®allantoic acid®urea®NH4+
    2. uric acid ® allantoic acid®urea®NH4+
    3. uric acid ®allantoin® urea®NH4+
    4. uric acid ®allantoin®allantoic acid®urea
    5. none of the above

Ans: A

Section:            23.4.B

Level of Difficulty: Easy

Learning Objective: Nucleotide Degradation

  1. The disease gout is characterized by high levels of ____, which forms crystal deposits in joints and is treated by inhibition of _______.
    1. uric acid; urate oxidase
    2. uric acid; xanthine oxidase
    3. urea; urate oxidase
    4. xanthine; xanthine oxidase
    5. none of the above

Ans:  B

Section: 23.4.B

Level of Difficulty: Moderate

Learning Objective: Nucleotide Degradation

 

  1. The end products of pyrimidine catabolism are
    1. uric acid and glyoxylic acid.
    2. uric acid and allantoin.
    3. b-alanineand b-aminoisobutyrate.
    4. b-alanine and a-ketoglutarate.
    5. none of the above

Ans: C

Section: 23.4.A

Level of Difficulty: Moderate

Learning Objective: Nucleotide Degradation

 

  1. The symptoms of severe combined immunodeficiency syndrome (SCID) are caused by a deficiency of which of the following enzymes?
    1. adenine phosphoribosyltransferase
    2. HGPRT (hypoxanthine–guanine phosphoribosyltransferase)
    3. adenosine deaminase
    4. dihydrofolate reductase
    5. xanthine oxidase

Ans:  C

Section: 23.4.A

Level of Difficulty: Easy

Learning Objective: Nucleotide Degradation

 

 

 

 

 

 

 

 

 

 

 

 

  1. The synthesis of 5-phosphoribosylamine from PRPP is
  2. inhibited allosterically by ATP and GTP.
  3. activated by PRPP via feed forward activation.

III. controlled by cAMP dependent phosphorylation.

  1. I, II, III,
  2. I, II
  3. II, III
  4. II only
  5. III only

Ans:  B

Section:  23.1.C

Level of Difficulty: Moderate

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Addition of pyrophosphate to which of the following occurs during the first step of purine biosynthesis?
    1. 5-phosphoribosyl phosphate
    2. ribulose-5-phosphate
    3. ribose-5-phosphate
    4. ribose
    5. phosphribosylamine

Ans:  C

Section: 23.1.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Which of the following pathways produces the sugar moiety used for nucleotide synthesis?
    1. glycolysis
    2. Calvin cycle
    3. pentose phosphate
    4. glycogen metabolism
    5. none of the above

Ans:  C

Section: 23.1.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. The amino group added to the C6 position of IMP to form AMP is derived from
    1. a-ketoglutarate.

Ans: A

Section: 23.1.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. The amino group added to the C2 position on IMP to form GMP is derived from
    1. aspartate
    2. aspargine
    3. glutamine
    4. a-ketoglutarate
    5. arginine

Ans: C

Section: 23.1.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Orotate is synthesized from
    1. glycine and carbamoyl phosphate.
    2. arginine and carbamoyl phosphate.
    3. aspartate and carbamoyl phosphate.
    4. aspartate and glutamine.
    5. asparagine and glutamine.

Ans: C

Section: 23.2.A

Level of Difficulty: Moderate

Learning Objective: Synthesis of Pyrimidine Ribonucleotides

 

  1. Which best describes the synthesis of purine nucleotides?
    1. The basic ring structure, orotate, is synthesized and then linked to PRPP. This is then modified to produce either GMP or AMP.
    2. The basic ring structure, inosine, is synthesized and then linked to PRPP. This is then modified to produce either GMP or AMP.
    3. The basic ring structure, orotate, is synthesized stepwise on PRPP. This is then modified to produce either GMP or AMP.
    4. The basic ring structure, inosine, is synthesized stepwise on PRPP. This is then modified to produce either GMP or AMP.
    5. The basic ring structure, orotate, is synthesized and then linked to PRPP. This is then modified to produce either UMP or CMP.

Ans: D

Section: 23.1.A, 23.1.B

Level of Difficulty:  Moderate

Learning Objective: Synthesis of Purine Ribonucleotides

 

 

 

 

 

 

 

  1. Individuals that do not consume adequate folic acid have serious problems with the
    1. synthesis of dATP.
    2. synthesis of dCTP.
    3. synthesis of dGTP.
    4. synthesis of dTTP.
    5. all of the above

Ans: B

Section: 23.1.A, 23.3.B

Level of Difficulty: Difficult

Learning Objective: Synthesis of Purine Ribonucleotides, Formation of Deoxyribonucleotides

 

  1. What category of reaction converts orotate monophosphate (OMP) into uracil monophosphate (UMP)?
    1. a transamination
    2. a methylation
    3. a decarboxylation
    4. a carboxylation
    5. none of the above

 

Ans: C

Section: 23.2.B

Level of Difficulty: Moderate

Learning Objective: Synthesis of Pyrimidine Ribonucleotides

 

  1. Which of the following statements is TRUE?
    1. PRPP is an effective feedback inhibitor of nucleotide synthesis.
    2. GTP serves as the energy input for AMP synthesis from IMP.
    3. Oxidation of ribosyl moieties to produce deoxynucleotides occurs at the diphosphate level.
    4. Thymidylate synthase methylates dUTP to produce dTTP.
    5. All of the above are true.

Ans: B

Section: 23.1.B

Level of Difficulty: Moderate

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Which of the following reactions is NOT catalyzed by nucleoside diphosphate kinase?
    1. GDP + ATP ® GTP + ADP
    2. UDP + ATP ® UTP + ADP
    3. CDP + ATP ® CTP + ADP
    4. dGDP + ATP ® dGTP + ADP
    5. It catalyzes all the above.

Ans: C

Section: 23.1.B, 23.3.A

Level of Difficulty: Difficult

Learning Objective: Synthesis of Purine Ribonucleotides, Formation of Deoxyribonucleotides

 

  1. Which of the following is correct regarding pyrimidine synthesis?
    1. carbamoyl phosphate + PRPP      aspartate + Pi + dihydroorotate
    2. carbamoyl phosphate + aspartate + quinone      Orotate + Pi +   H2O + reduced quinone
    3. dihydroorotate + quinone orotate + reduced quinine
    4. A and C
    5. None of the above

Ans: B

Section: 23.2.A

Level of Difficulty: Difficult

Learning Objective: Synthesis of Pyrimidine Ribonucleotides

 

  1. In animals, elevated levels of PRPP will
    1. activate pyrimidine biosynthesis.
    2. activate purine biosynthesis.
    3. activate both pyrimidine and purine biosynthesis.
    4. inhibit pyrimidine biosynthesis; activate purine biosynthesis.
    5. inhibit purine biosynthesis; activate pyrimidine biosynthesis.

 

Ans: C

Section: 23.1.C; 23.2.C

Level of Difficulty: Moderate

Learning Objective: Synthesis of Purine Ribonucleotides and Synthesis of Pyrimidine

Ribonecleotides

 

 

 

 

Using the diagram above, answer questions 43 – 45.  C may be used to represent either or both of the atoms labeled C.

 

  1. Glycine contributes to the ring at position _____.
    1. A
    2. B
    3. C
    4. D
    5. E

Ans: E

Section: 23.1.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Formate contributes to the ring at position _____.
    1. A
    2. B
    3. D
    4. B, D
    5. F

Ans: B

Section: 23.1.A

Level of Difficulty: Easy

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. Rank the additions to the rings in order of formation.
    1. C, B, A, F, D, E
    2. C, E, D, C, F, A, B
    3. A, C ,D ,E ,F ,B
    4. D, F, A, C, B, E
    5. C, F, A, C, B ,E ,D

Ans: B

Section: 23.1.A

Level of Difficulty: Difficult

Learning Objective: Synthesis of Purine Ribonucleotides

 

  1. A final common product from both purine degradation and pyrimidine degradation is
    1. uric acid.
    2. ribose-1-phosphate.
    3. ribose-5-phosphate.
    4. malonyl-CoA.

Ans: B

Section: 23.4.A and C

Level of Difficulty: Moderate

Learning Objective: Nucleotide Degradation

 

  1. The last step in purine degradation
  2. generates hydrogen peroxide as a byproduct.
  3. utilizes molecular oxygen.

III. is inhibited by methotrexate.

  1. requires NAD+.
    1. I, II, III, IV
    2. I, II, IV
    3. II, IV
    4. I, II, IV
    5. I, II

Ans: E

Section: 23.4.A

Level of Difficulty: Difficult

Learning Objective: Nucleotide Degradation

 

  1. Recombinant forms of the enzyme urate oxidase are available for therapeutic purposes. Based on the information in this chapter, in which of the following conditions might this therapy be useful?
    1. myoadenylate deaminase deficiency
    2. severe combined immunodeficiency disease
    3. gout
    4. toxoplasmosis
    5. folate deficiency

Ans: C

Section: 23.4.B

Level of Difficulty: Difficult

Learning Objective: Nucleotide Degradation

 

  1. The anticancer drug methotrexate inhibits nucleotide synthesis. Which of the following explains why it also inhibits the synthesis of histidine and methionine?
    1. The synthetic pathways for these amino acids require tetrahydrofolate for group transfer reactions.
    2. These amino acids are derivatives of the nucleotides UTP and GTP.
    3. Without the synthesis of nucleotides, there is not sufficient energy for the synthesis of the amino acids.
    4. <ethotrexate inhibits also inhibits the precursors for these amino acids.
    5. all of the above

Ans: A

Section: 23.3.B

Level of Difficulty: Difficult

Learning Objective: Formation of Deoxyribonucleotides

 

  1. Acyclovir is a derivative of which of the following?
    1. a pyrimidine
    2. a purine
    3. malonic semialdehyde
    4. dihydrofolate
    5. thioredoxin

Ans: B

Section: 23.4.B

Level of Difficulty: Easy

Learning Objective: Nucleotide Degradation