Rang and Dale Pharmacology 7th Edition Ritter Flower Henderson Rang Test Bank
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Below you will find some free nursing test bank questions from this test bank:
Rang: Rang & Dale’s Pharmacology, 7th Edition
Chapter 55: Anticancer drugs
- A cytoplasmic kinase (Bcr/Abl) involved in the pathogenesis of chronic myeloid leukemia is inhibited by
Answer c: imatinib
- Cumulative dose-related cardiac toxicity typically results from administration of
Answer a: doxorubicin
- Goserelin is used in treating advanced prostate cancer because of its ability to
- increase gonadotrophin secretion
- reduce gonadotrophin secretion
- block testosterone receptors
- activate estrogen receptors
- inhibit estrogen synthesis
Answer b: reduce gonadotrophin secretion
- Vincristine inhibits mitosis of cancer cells at metaphase by
- inhibiting telomerase
- increasing tubulin degradation
- inhibiting synthesis of tubulin
- inhibiting polymerization of tubulin
- stabilizing microtubules
Answer d: inhibiting polymerization of tubulin
- Cytarabine is converted to an active triphosphate metabolite that inhibits
- DNA polymerase
- adenine deaminase
- dihydrofolate reductase
- thymidylate synthetase
Answer a: DNA polymerase
- Folinic acid can be administered to counteract the toxic effects of
Answer e: methotrexate
- Reactive carbonium ions that attack guanine bases of DNA and lead to crosslinking of DNA strands are formed in the body from drugs such as
Answer e: cyclophosphamide
- Which anticancer drug is most effective in the G2 phase of the cell cycle?
Answer c: bleomycin
- Thymidylate synthetase is inhibited by the active metabolite of
Answer b: fluorouracil
- Anastrozole is used in treating advanced breast cancer because of its ability to
- inactivate tumor growth factors
- block estrogen receptors
- inhibit aromatase
- decrease gonadotropin secretion
- cross-link strands of DNA
Answer c: inhibit aromatase
- Sulfhydryl donors such as mesna are useful in reducing ifosfamide-induced
- bone marrow depression
- nausea and vomiting
- cardiac toxicity
- hemorrhagic cystitis
- gastrointestinal ulceration
Answer d: hemorrhagic cystitis
- Trastuzumab is useful in treating breast cancer because of its ability to bind
- human epidermal growth factor receptor 2
- DNA transcription factors
- insulin-like growth factor
- calcium channel forming proteins
Answer b: human epidermal growth factor receptor 2