Description
Rang and Dale Pharmacology 7th Edition Ritter Flower Henderson Rang Test Bank
ISBN: 9780702062193
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Rang: Rang & Dale’s Pharmacology, 7th Edition
Test Bank
Chapter 55: Anticancer drugs
MULTIPLE CHOICE
- A cytoplasmic kinase (Bcr/Abl) involved in the pathogenesis of chronic myeloid leukemia is inhibited by
- crisantaspase
- anastrozole
- imatinib
- rituximab
- aldesleukin
Answer c: imatinib
- Cumulative dose-related cardiac toxicity typically results from administration of
- doxorubicin
- bleomycin
- vincristine
- imatinib
- irinotecan
Answer a: doxorubicin
- Goserelin is used in treating advanced prostate cancer because of its ability to
- increase gonadotrophin secretion
- reduce gonadotrophin secretion
- block testosterone receptors
- activate estrogen receptors
- inhibit estrogen synthesis
Answer b: reduce gonadotrophin secretion
- Vincristine inhibits mitosis of cancer cells at metaphase by
- inhibiting telomerase
- increasing tubulin degradation
- inhibiting synthesis of tubulin
- inhibiting polymerization of tubulin
- stabilizing microtubules
Answer d: inhibiting polymerization of tubulin
- Cytarabine is converted to an active triphosphate metabolite that inhibits
- DNA polymerase
- adenine deaminase
- dihydrofolate reductase
- telomerase
- thymidylate synthetase
Answer a: DNA polymerase
- Folinic acid can be administered to counteract the toxic effects of
- fludarabine
- gemcitabine
- cytarabine
- fluorouracil
- methotrexate
Answer e: methotrexate
- Reactive carbonium ions that attack guanine bases of DNA and lead to crosslinking of DNA strands are formed in the body from drugs such as
- cisplatin
- bleomycin
- doxorubicin
- etoposide
- cyclophosphamide
Answer e: cyclophosphamide
- Which anticancer drug is most effective in the G2 phase of the cell cycle?
- paclitaxel
- methotrexate
- bleomycin
- irinotecan
- cytarabine
Answer c: bleomycin
- Thymidylate synthetase is inhibited the active metabolite of
- pentostatin
- fluorouracil
- doxorubicin
- gemcitabine
- fludarabine
Answer b: fluorouracil
- Anastrozole is used in treating advanced breast cancer because of its ability to
- inactivate tumor growth factors
- block estrogen receptors
- inhibit aromatase
- decrease gonadotropin secretion
- cross-link strands of DNA
Answer c: inhibit aromatase
- Sulfhydryl donors such as mesna are useful in reducing ifosfamide-induced
- bone marrow depression
- nausea and vomiting
- cardiac toxicity
- hemorrhagic cystitis
- gastrointestinal ulceration
Answer d: hemorrhagic cystitis
- Trastuzumab is useful in treating breast cancer because of its ability to bind
- telomerase
- human epidermal growth factor receptor 2
- DNA transcription factors
- insulin-like growth factor
- calcium channel forming proteins
Answer b: human epidermal growth factor receptor 2