Description

Rang and Dale Pharmacology 7^th Edition Ritter Flower Henderson Rang Test Bank

ISBN: 9780702062193

 

 

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Below you will find some free nursing test bank questions from this test bank:

 

Rang: Rang & Dale’s Pharmacology, 7^th Edition

 

Test Bank

 

Chapter 55:  Anticancer drugs

 

MULTIPLE CHOICE

 

1. A cytoplasmic kinase (Bcr/Abl) involved in the pathogenesis of chronic myeloid leukemia is inhibited by

 

1. crisantaspase
2. anastrozole
3. imatinib
4. rituximab
5. aldesleukin

 

Answer c: imatinib

 

1. Cumulative dose-related cardiac toxicity typically results from administration of

 

1. doxorubicin
2. bleomycin
3. vincristine
4. imatinib
5. irinotecan

 

Answer a: doxorubicin

 

1. Goserelin is used in treating advanced prostate cancer because of its ability to

 

1. increase gonadotrophin secretion
2. reduce gonadotrophin secretion
3. block testosterone receptors
4. activate estrogen receptors
5. inhibit estrogen synthesis

 

Answer b: reduce gonadotrophin secretion

 

1. Vincristine inhibits mitosis of cancer cells at metaphase by

 

1. inhibiting telomerase
2. increasing tubulin degradation
3. inhibiting synthesis of tubulin
4. inhibiting polymerization of tubulin
5. stabilizing microtubules

 

Answer d: inhibiting polymerization of tubulin

 

1. Cytarabine is converted to an active triphosphate metabolite that inhibits

 

1. DNA polymerase
2. adenine deaminase
3. dihydrofolate reductase
4. telomerase
5. thymidylate synthetase

 

Answer a: DNA polymerase

 

1. Folinic acid can be administered to counteract the toxic effects of

 

1. fludarabine
2. gemcitabine
3. cytarabine
4. fluorouracil
5. methotrexate

 

Answer e: methotrexate

 

1. Reactive carbonium ions that attack guanine bases of DNA and lead to crosslinking of DNA strands are formed in the body from drugs such as

 

1. cisplatin
2. bleomycin
3. doxorubicin
4. etoposide
5. cyclophosphamide

 

Answer e: cyclophosphamide

 

1. Which anticancer drug is most effective in the G2 phase of the cell cycle?

 

1. paclitaxel
2. methotrexate
3. bleomycin
4. irinotecan
5. cytarabine

 

Answer c: bleomycin

 

1. Thymidylate synthetase is inhibited the active metabolite of

 

1. pentostatin
2. fluorouracil
3. doxorubicin
4. gemcitabine
5. fludarabine

 

Answer b: fluorouracil

 

1. Anastrozole is used in treating advanced breast cancer because of its ability to

 

1. inactivate tumor growth factors
2. block estrogen receptors
3. inhibit aromatase
4. decrease gonadotropin secretion
5. cross-link strands of DNA

 

Answer c: inhibit aromatase

 

1.  Sulfhydryl donors such as mesna are useful in reducing ifosfamide-induced

 

1. bone marrow depression
2. nausea and vomiting
3. cardiac toxicity
4. hemorrhagic cystitis
5. gastrointestinal ulceration

 

Answer d: hemorrhagic cystitis

 

1. Trastuzumab is useful in treating breast cancer because of its ability to bind

 

1. telomerase
2. human epidermal growth factor receptor 2
3. DNA transcription factors
4. insulin-like growth factor
5. calcium channel forming proteins

 

Answer b: human epidermal growth factor receptor 2